Salem A, Little RA, Latif A, Babur M, Featherstone AK, Peset I, Cheung S, Watson Y, Tessyman V, Berks M, Mistry H, Ashton G, Behan C, Matthews JC, Asselin M-C, Bristow RG, Jackson A, Parker GLM, Faivre-Finn C, Williams KJ, O’Connor JPB. Oxygen-enhanced MRI is feasible, repeatable and detects radiotherapy-induced change in hypoxia in xenograft models and in patients with non-small cell lung cancer. Clin Cancer Res 25: 3818-29. Editor’s highlights. doi: 10.1158/1078-0432.CCR-18-3932

Marti FEM, Jayson GC, Manoharan P, O’Connor J, Renehan A, Backen A, Mistry H, Ortega F, Li K, Simpson KL, Allen J, Connell J, Underhill S, Misra V, Williams KJ, Stratford I, Jackson A, Dive C, Saunders MP. Novel phase I trial to evaluate the addition of cediranib or selumetinib to preoperative chemoradiotherapy for locally advanced rectal cancer: the DREAMtherapy trial. Euro J Cancer 117: 48-59. doi:  10.1016/j.ejca.2019.04.029

McHugh DJ, Hubbard Cristinacce PL, Naish JH, Parker GJM. Towards a ‘resolution limit’ for DW-MRI tumour microstructural models: a simulation study investigating the feasibility of distinguishing between microstructural changes. Magn Reson Med 81: 2288-2301. doi: 10.1002/mrm.27551

Tijssen RHN, Philippens MEP, Paulson ES, Glitzner M, Chugh B, Wetscherek A, Dubec M, Wang J, van der Heide UA. MRI commissioning of 1.5T MR-linac systems – a multi-institutional study. Radiother Oncol 132: 114-120. doi:  10.1016/j.radonc.2018.12.011


Jayson GC, Zhou C, Backen A, Horsley L, Marti-Marti K, Shaw D, Mescallado N, Clamp AJ, Saunders MP, Valle J, Mullamitha S, Braun M, Hasan J, Goonetilleke D, McEntee D, Simpson KL, Little RA, Watson Y, Cheung S, Roberts C, Ashcroft L, Manoharan P, Scherer S, del Puerto O, Jackson A, O’Connor JPB, Parker GJM, Dive C. Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer.Nat Commun 9: 4672. doi:  10.1038/s41467-018-07174-1

Zhou F-L, Li Z, Gough J, Hubbard Cristinacce PL, Parker GJM. Axon mimicking hydrophilic hollow polycaprolactone microfibres for diffusion magnetic resonance imaging. Materials & Design 137: 394–403. doi: 10.1016/j.matdes.2017.10.047

Little RA, Barjat H, Hare JI, Jenner M, Watson Y, Cheung S, Holliday K, Zhang W, O’Connor JPB, Barry ST, Puri S, Parker GJM, Waterton JC. Evaluation of dynamic contrast-enhanced MRI biomarkers for stratified cancer medicine: How do permeability and perfusion vary between human tumours? Magn Reson Imag 46: 98-105. doi: 10.1016/j.mri.2017.11.008

McHugh DJ, Zhou F-L, Wimpenny I, Poologasundarampillai G, Naish JH, Hubbard Cristinacce PL, Parker GJM. A biomimetic tumor tissue phantom for validating diffusion‐weighted MRI measurements. Magn Reson Med 80: 147-158. doi: 10.1002/mrm.27016Featherstone AK, O’Connor JPB, Little RA, Watson Y, Cheung S, Babur M, Williams KJ, Matthews JC, Parker GJM. Optimized data-driven mapping of hypoxia-related tumor heterogeneity using DCE-MRI and OE-MRI. Magn Reson Med 79: 2236-2245. doi: 10.1002/mrm.26860

Little RA, Jamin Y, Boult JKR, Naish JH, Watson Y, Cheung S, Holliday KF, Lu H, Morris DM, McHugh D, Reynolds AR, Maddineni S, Parker GJM, Clarke NW, Waterton JC, Robinson SP, O’Connor JPB. Mapping Hypoxia in Renal Carcinoma with Oxygen-enhanced MRI: Comparison with Intrinsic Susceptibility MRI and Pathology. Radiology 288: 739-747. doi: 10.1148/radiol.2018171531

Jones, DK, Alexander DC, Bowtell R, Cercignani M, Dell’Acqua F, McHugh DJ, Miller KL, Palombo M, Parker GJM, Rudrapatna US, Tax CMW. Microstructural imaging of the human brain with a ‘super-scanner’: 10 key advantages of ultra-strong gradients for diffusion MRI. NeuroImage 182: 8-38. doi: 10.1016/j.neuroimage.2018.05.047

Berks M. Dinsdale G, Murray A, Moore T, Manning J, Taylor C, Herrick AL. Automated structure and flow measurement — a promising tool in nailfold capillaroscopy. Microvasc Res 118: 173-177. doi:  10.1016/j.mvr.2018.03.016


Tomaszewski MR, Quiros Gonzalez I, Abeyakoon O, Parker GJM, Williams KJ, O’Connor JPB, Gilbert F, Bohndiek SE. Oxygen enhanced optoacoustic tomography (OE-OT) reveals vascular dynamics in prostate cancer xenografts. Theranostics 7: 2900-13. doi: 10.7150/thno.19841. Editorial.


O’Connor JPB, Boult JKR, Jamin Y, Babur M, Finegan KG, Williams KJ, Little RA, Jackson A, Parker GJM, Reynolds AR, Waterton JC, Robinson SP. Oxygen enhanced MRI accurately identifies and maps tumor hypoxia in preclinical cancer models. Cancer Res 76: 787-95 doi: 10.1158/0008-5472.CAN-15-2062, Front cover plus editorial.

Wallace TE, Patterson AJ, Abeyakoon O, Bedair R, Manavaki R, McLean MA, O’Connor JPB, Graves MJ, Gilbert FJ. Detecting gas-induced vasomotor changes via blood oxygenation level-dependent contrast in healthy breast parenchyma and breast carcinoma. J Magn Reson Imag 44: 335-45.  doi: 10.1002/jmri.25177


McHugh DJ, Zhou F, Hubbard Cristinacce PL, Naish JH, Parker GJM. Ground Truth for Diffusion MRI in Cancer: A Model-Based Investigation of a Novel Tissue-Mimetic Material. In S. Ourselin et al. (Eds.): Information Processing in Medical Imaging (IPMI’15), Lect Notes Comp Sci 9123: 179-190. doi: 10.1007/978-3-319-19992-4_14

Doblas S, Almeida GS, Blé FX, Garteiser P, Hoff BA, McIntyre DJO, Wachsmuth L, Chenevert TL, Faber C, Griffiths JR, Jacobs AH, Morris DM, O’Connor JPB, Robinson SP, Van Beers BE, Waterton JC. Apparent diffusion coefficient is highly reproducible on preclinical imaging systems: evidence from a seven-centre multivendor study. J Magn Reson Imag 42: 1759-1764 doi: 10.1002/jmri.24955

Ferl GZ, O’Connor JPB, Parker GJM, Carano RAD, Acharya S, Port RE. Mixed-effects modeling of clinical DCE-MRI data: application to colorectal liver metastases treated with bevacizumab. J Magn Reson Imag 41: 132-141. doi: 10.1002/jmri.24514


Linnik IV, Scott M, Holliday K, Woodhouse N, Waterton JC, O’Connor JPB, Barjat H, Liess C, Ulloa J, Young H, Dive C, Hodgkinson CL, Ward T, Roberts D, Mills SJ, Thompson G, Buonaccorsi GA, Cheung S, Jackson A, Naish JH, Parker GJM. Non-invasive tumor hypoxia measurement using magnetic resonance imaging in U87 and human glioblastoma. Magn Reson Med 71: 1854-1862 doi: 10.1002/mrm.24826

Rose CJ, O’Connor JPB, Cootes TF, Taylor CJ, Naish JH, Parker GJM, Waterton JC. Indexed Distribution Analysis for Improved Significance Testing of Spatially Heterogeneous Parameter Maps: Application to Dynamic Contrast-Enhanced MRI Biomarkers. Magn Reson Med 71: 1299-1311. doi: 10.1002/mrm.24755

Crabb MG, Davidson JL, Little R, Wright P, Morgan AR, Miller CA, Naish JH, Parker, GJM, Kikinis R, McCann H, Lionheart WRB. Mutual information as a measure of image quality for 3D dynamic lung imaging with EIT. Physiological Measurement 35: 863-879. doi: 10.1088/0967-3334/35/5/863


Horsley L, Cummings J, Middleton M, Ward T, Backen A, Clamp A, Dawson M, Farmer H, Fisher N, Halbert G, Halford S, Harris A, Hasan J, Hogg P, Kumaran G, Little RA, Parker GJM, Potter P, Saunders M, Roberts C, Shaw D, Smith N, Smythe J, Taylor A, Turner H, Watson Y, Dive C, Jayson GC. A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours. Cancer Chemother Pharmacol 72: 1343-1352. doi: 10.1007/s00280-013-2320-9


Banerji A, Naish JH, Watson Y, Jayson GC, Buonaccorsi GA, Parker GJM. DCE-MRI model selection for investigating disruption of microvascular function in livers with metastatic disease. J Magn Reson Imag 35: 196-203. doi: 10.1002/jmri.22692

Davidson JL, Little RA, Wright P, Naish JH, Kikinis R, Parker GJM, McCann H. Fusion of images obtained from EIT and MRI. Electronics Letters 48: 617-618.  doi: 10.1049/el.2012.0327


Greystoke A, O’Connor JPB, Linton K, Taylor MB, Cummings J, Ward T, Maders F, Hughes A, Ranson M, Illidge TM, Radford JA, Dive C. Assessment of circulating biomarkers for potential prognostic, predictive and pharmacodynamic utility in patients with lymphoma. Br J Cancer 104: 719-725. doi: 10.1038/sj.bjc.6606082

Roberts C, Little R, Watson Y, Zhao S, Buckley DL, Parker GJM. The effect of blood inflow and B1-field inhomogeneity on measurement of the arterial input function in axial 3D spoiled gradient echo dynamic contrast-enhanced MRI. Magn Reson Med 65: 108-119. doi: 10.1002/mrm.22593

O’Connor JPB, Rose CJ, Jackson A, Watson Y, Cheung S, Jayson GC, Whitcher B, Roberts C, Buonaccorsi GA, Maders F, Thompson G, Parker GJM. Measuring tumor vascular heterogeneity improves prediction of therapeutic response in CRC metastases treated with bevacizumab and FOLFOX-6. Br J Cancer 105: 139-145. doi: 10.1038/bjc.2011.191

Naish JH, McGrath DM, Bains LJ, Passera K, Roberts C, Watson Y, Cheung S, Taylor MB, Logue JP, Buckley DL, Tessier J, Young H, Waterton JC, Parker GJM. Comparison of dynamic contrast-enhanced MRI and dynamic contrast-enhanced CT biomarkers in bladder cancer. Magn Reson Med 66: 219-226. doi: 10.1002/mrm.22774

Mitchell CL, O’Connor JP, Roberts C, Watson Y, Jackson A, Cheung S, Evans J, Spicer J, Harris AL, Kelly C, Rudman S, Middleton M, Fielding A, Tessier J, Young H, Parker GJ, Jayson GC. A two-part phase II study of cediranib in patients with advanced solid tumours: the effect of food on single-dose pharmacokinetics and an evaluation of safety, efficacy and imaging pharmacodynamics. Cancer Chemother Pharmacol 68: 631-641. doi: 10.1007/s00280-010-1534-3


Buonaccorsi GA, Rose CJ, O’Connor JPB, Roberts C, Watson Y, Jackson A, Jayson GC, Parker GJM. Cross-Visit Tumor Sub-segmentation and Registration with Outlier Rejection for Dynamic Contrast-Enhanced MRI Time Series Data. Lect Notes Comp Sci 6363: 121-128. doi: 10.1007/978-3-642-15711-0_16

Donaldson SB, Buckley DL, O’Connor JP, Davidson SE, Carrington BM, Jones AP, West CML. Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix. Br J Cancer 102: 23-26. doi: 10.1038/sj.bjc.6605415

Mills SJ, Soh C, O’Connor JPB, Rose CJ, Buonaccorsi G, Cheung S, Zhao S, Parker GJM, Jackson A. Enhancing fraction in glioma and its relationship to the tumoral vascular microenvironment: a dynamic contrast-enhanced MR imaging study. Am J Neuroradiol 31: 726-731 doi: 10.3174/ajnr.A1925

Bains LJ, McGrath DM, Naish JH, Cheung S, Watson Y, Taylor MB, Logue JP, Parker GJM, Waterton JC, Buckley DL. Tracer kinetic analysis of dynamic contrast-enhanced MRI and CT data: A preliminary comparison to assess the magnitude of water exchange effects. Magn Reson Med 64: 595–603. doi: 10.1002/mrm.22430

Mitchell CL, O’Connor JPB, Jackson A, Parker GJM, Roberts C, Watson Y, Cheung S, Davies K, Buonaccorsi GA, Clamp AR, Hasan J, Byrd L, Backen A, Dive C, Jayson GC. Identification of early predictive imaging biomarkers and their relationship to serological angiogenic markers in patients with ovarian cancer with residual disease following cytotoxic therapy. Annals Oncology 21: 1982-1989.  doi: 10.1093/annonc/mdq079


O’Connor JPB, Carano RAD, Clamp AR, Ross J, Ho CCK, Jackson A, Parker GJM, Rose CJ, Peale FV, Friesenhahn M, Mitchell CL, Watson Y, Roberts C, Hope L, Cheung S, Buonaccorsi GA, Reslan HB, Go MAT, Pacheco GJ, Wu X, Cao TC, Ross S, Davies K, Hasan J, Thornton P, del Puerto O, Ferrara N, van Bruggen N, Jayson GC. Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: insights from imaging. Clin Cancer Res 15: 6674-6682 doi: 10.1158/1078-0432.CCR-09-0731

O’Connor JPB, Naish JH, Parker GJM, Waterton JC, Watson Y, Jayson GC, Buonaccorsi GA, Cheung S, Buckley DL, McGrath DM, West CML, Davidson SE, Roberts C, Mills SJ, Mitchell CL, Hope L, Ton NC, Jackson A. Preliminary study of oxygen-enhanced longitudinal relaxation in MRI: a potential novel biomarker of oxygenation in solid tumors. IJROBP 75: 1209-1215. doi: 10.1016/j.ijrobp.2008.12.040

Rose CJ, Mills SJ, O’Connor JPB, Buonaccorsi GA, Roberts C, Watson Y, Cheung S, Zhao S, Whitcher B, Jackson A, Parker GJM. Quantifying spatial heterogeneity in dynamic contrast-enhanced MRI parameter maps. Magn Reson Med 62: 488-499 doi: 10.1002/mrm.22003

Mills SJ, Soh C, O’Connor JPB, Rose CJ, Buonaccorsi GA, Cheung S, Zhao S, Parker GJM, Jackson A. Tumour enhancing fraction (EnF) in Glioma: relationship to tumour grade. Euro Radiology 19: 1489-1498. doi: 10.1007/s00330-008-1288-z

O’Connor JPB, Naish JN, Jackson A, Waterton, JC, Watson Y, Cheung S, Buckley DL, McGrath DM, Buonaccorsi GA, Mills SJ, Roberts C, Jayson GC, Parker GJM. Comparison of normal tissue R1 and R2* modulation by oxygen and carbogen. Magn Reson Med 61: 75-83 doi: 10.1002/mrm.21815